TGIF1 Polyclonal Antibody (CAB16984)
- SKU:
- CAB16984
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
Product Name: | TGIF1 Polyclonal Antibody |
SKU: | CAB16984 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-340 of human TGIF1 (NP_733796.2). |
Sequence: | SSVE SVMG IKNF MPAL EETP FHSC TAGP NPTL GRPL SPKP SSPG SVLA RPSV ICHT TVTA LKDV PFSL CQSV GVGQ NTDI QQIA AKNF TDT |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | HPE4; TGIF; TGIF1 |
Positive Sample: | HepG2,MCF7,K-562,U-251MG,Mouse liver,Mouse testis,Rat uterus |
Cellular Localization: | nucleoplasm |
Calculated MW: | 43kDa |
Observed MW: | 35kDa |
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.
Purification Method: | Affinity purification |
Gene ID: | 7050 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |