The TGFBR3 Polyclonal Antibody (CAB0627) is a valuable tool for researchers studying TGFBR3, a critical receptor involved in the TGF-β signaling pathway. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot assays. By binding specifically to TGFBR3, this antibody enables researchers to detect and analyze the expression of the receptor in various cell types, providing insight into its role in cell signaling and disease.TGFBR3, also known as Betaglycan, acts as a coreceptor for TGF-β ligands, modulating their signaling activity and influencing various cellular processes including proliferation, differentiation, and apoptosis.
Dysregulation of TGF-β signaling, including alterations in TGFBR3 expression or function, is associated with numerous diseases such as cancer, fibrosis, and immune disorders. Investigating the role of TGFBR3 using this polyclonal antibody can provide valuable information for understanding the molecular mechanisms underlying these pathologies and identifying potential therapeutic targets.
Product Name:
TGFBR3 Rabbit Polyclonal Antibody
SKU:
CAB0627
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 140-340 of human TGFBR3 (NP_003234.2).
Cell membrane, Secreted, Single-pass type I membrane protein, extracellular space.
Calculated MW:
93kDa
Observed MW:
110kDa
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
7049
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TGFBR3 antibody (CAB0627) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
