TGF beta Receptor II (TGFBR2) Rabbit Polyclonal Antibody (CAB1415)
The TGFBR2 Polyclonal Antibody (CAB1415) is a valuable tool for researchers studying TGFBR2, a key receptor involved in the transforming growth factor beta (TGFβ) signaling pathway. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TGFBR2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in areas such as cell signaling, developmental biology, and cancer research.TGFBR2 plays a crucial role in regulating cell growth, differentiation, and apoptosis, making it a key player in various biological processes.
Dysregulation of the TGFβ signaling pathway has been implicated in various diseases, including cancer, fibrosis, and immune disorders. Therefore, understanding the function of TGFBR2 and its downstream signaling pathways is essential for developing targeted therapies for these conditions.Overall, the TGFBR2 Polyclonal Antibody (CAB1415) is a reliable tool for researchers looking to study the role of TGFBR2 in various biological processes and diseases. Its specificity and sensitivity make it a valuable asset for studies aiming to elucidate the molecular mechanisms underlying TGFβ signaling and its implications in human health and disease.
Product Name:
TGF beta Receptor II (TGFBR2) Rabbit Polyclonal Antibody
SKU:
CAB1415
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-280 of human TGF beta Receptor II (TGFBR2) (NP_003233.4).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
65kDa
Observed MW:
70kDa, 85kDa
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Purification Method:
Affinity purification
Gene ID:
7048
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TGF beta Receptor II (TGFBR2) Rabbit pAb (CAB1415) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
