TGF beta Receptor II (TGFBR2) Rabbit Polyclonal Antibody (CAB1415)
- SKU:
- CAB1415
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | TGF beta Receptor II (TGFBR2) Rabbit Polyclonal Antibody |
SKU: | CAB1415 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-280 of human TGF beta Receptor II (TGFBR2) (NP_003233.4). |
Sequence: | TIPP HVQK SVNN DMIV TDNN GAVK FPQL CKFC DVRF STCD NQKS CMSN CSIT SICE KPQE VCVA VWRK NDEN ITLE TVCH DPKL PYHD FILE DAAS PKCI MKEK KKPG ETFF MCSC SSDE CNDN IIFS EEYN TSNP DLLL VIFQ VTGI SLLP PLGV AISV IIIF YCYR VNRQ QKLS STWE TGKT RKLM EFSE HCAI ILED DRSD ISST CANN INHN TELL PIEL DTLV GKGR FAEV YKAK LKQN TSEQ FETV AVKI FP |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; tbetaR-II; TGFbeta-RII; TGF beta Receptor II (TGFBR2) |
Positive Sample: | Mouse brain,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 65kDa |
Observed MW: | 70kDa, 85kDa |
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Purification Method: | Affinity purification |
Gene ID: | 7048 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |