TGF beta Receptor II (TGFBR2) Rabbit Polyclonal Antibody (CAB11788)
The TGFBR2 Polyclonal Antibody (CAB11788) is a valuable tool for research involving the TGFBR2 protein, a receptor involved in the transforming growth factor beta (TGF-β) signaling pathway. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds specifically to the TGFBR2 protein, allowing for accurate detection and analysis in various cell types, making it an excellent choice for studies in molecular biology, cancer research, and developmental biology.The TGFBR2 receptor plays a crucial role in regulating cell growth, differentiation, and apoptosis, making it a key player in various biological processes.
Dysregulation of the TGF-β signaling pathway, often involving mutations or aberrant expression of TGFBR2, has been implicated in many diseases, including cancer, fibrosis, and developmental disorders. Understanding the function and regulation of TGFBR2 is essential for developing targeted therapies that can modulate this signaling pathway in disease contexts.Overall, the TGFBR2 Polyclonal Antibody (CAB11788) provides researchers with a reliable tool for investigating the role of TGFBR2 in cellular processes and disease mechanisms, paving the way for potential therapeutic interventions targeting the TGF-β signaling pathway.
Product Name:
TGF beta Receptor II (TGFBR2) Rabbit Polyclonal Antibody
SKU:
CAB11788
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-280 of human TGF beta Receptor II (TGFBR2) (NP_003233.4).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
65kDa
Observed MW:
65-80kDa
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Purification Method:
Affinity purification
Gene ID:
7048
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TGF beta Receptor II (TGFBR2) Rabbit pAb (CAB11788) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
