TGF beta Receptor II (TGFBR2) Rabbit Polyclonal Antibody (CAB11765)
- SKU:
- CAB11765
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | TGF beta Receptor II (TGFBR2) Rabbit Polyclonal Antibody |
SKU: | CAB11765 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 237-549 of human TGF beta Receptor II (TGFBR2) (NP_003233.4). |
Sequence: | HNTE LLPI ELDT LVGK GRFA EVYK AKLK QNTS EQFE TVAV KIFP YEEY ASWK TEKD IFSD INLK HENI LQFL TAEE RKTE LGKQ YWLI TAFH AKGN LQEY LTRH VISW EDLR KLGS SLAR GIAH LHSD HTPC GRPK MPIV HRDL KSSN ILVK NDLT CCLC DFGL SLRL DPTL SVDD LANS GQVG TARY MAPE VLES RMNL ENVE SFKQ TDVY SMAL VLWE MTSR CNAV GEVK DYEP PFGS KVRE HPCV ESMK DNVL RDRG RPEI PSFW LNHQ GIQM VCET LTEC WDHD PEAR LTAQ CVAE RFSE LEHL DRLS G |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; tbetaR-II; TGFbeta-RII; TGF beta Receptor II (TGFBR2) |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 65kDa |
Observed MW: | 90kDa |
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Purification Method: | Affinity purification |
Gene ID: | 7048 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |