TGF beta Receptor I (TGFBR1) Rabbit Polyclonal Antibody (CAB0708)
The TGFBR1 Polyclonal Antibody (CAB0708) is a valuable tool for researchers studying the TGFBR1 protein, a key player in the TGF-β signaling pathway. This antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting TGFBR1 in human samples, making it an excellent choice for Western blot applications. By targeting the TGFBR1 protein, researchers can explore its role in various cellular processes, including cell growth, differentiation, and immune response modulation.TGFBR1, a type I receptor for the transforming growth factor beta (TGF-β) family of ligands, is involved in regulating cell proliferation, differentiation, and apoptosis. Dysregulation of TGFBR1 signaling has been implicated in numerous diseases, including cancer, fibrosis, and autoimmune disorders.
The TGFBR1 Polyclonal Antibody enables researchers to investigate the expression and activation of TGFBR1 in different cell types, offering insights into its function and potential therapeutic targets.With its specificity, sensitivity, and versatility in detecting TGFBR1, the CAB0708 antibody is an essential tool for researchers interested in unraveling the complexities of TGF-β signaling and its implications in health and disease. By understanding the role of TGFBR1, researchers can pave the way for the development of targeted therapies for a variety of medical conditions.
Product Name:
TGF beta Receptor I (TGFBR1) Rabbit Polyclonal Antibody
SKU:
CAB0708
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TGF beta Receptor I (TGFBR1) (NP_004603.1).
Sequence:
CCNQ DHCN KIEL PTTV KSSP GLGP VELA AVIA GPVC FVCI SLML MVYI CHNR TVIH HRVP NEED PSLD RPFI SEGT TLKD LIYD MTTS GSGS GLPL LVQR T
Cell junction, Cell membrane, Single-pass type I membrane protein, tight junction.
Calculated MW:
56kDa
Observed MW:
56kDa
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7046
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using TGF beta Receptor I (TGFBR1) Rabbit pAb (CAB0708) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
