From the information provided in the URL for the TGFB3 Polyclonal Antibody (CAB8460), we can create a product description as follows:The TGFB3 Polyclonal Antibody (CAB8460) is specifically designed for research involving TGFB3, a member of the transforming growth factor beta (TGF-β) superfamily known for its important role in cell growth, differentiation, and immune regulation. This antibody, produced in rabbits, displays high reactivity with human samples and is validated for use in various applications, including Western blotting.TGFB3 is a key player in numerous biological processes, including embryonic development, tissue repair, and immune response modulation. Its involvement in regulating cell proliferation and differentiation makes it a valuable target for studies in developmental biology, cancer research, and immunology.
The ability of this antibody to specifically bind to TGFB3 protein enables accurate detection and analysis in a variety of cell types, facilitating in-depth investigations into its functions and mechanisms of action.Researchers interested in unraveling the complexities of TGF-β signaling pathways or exploring the therapeutic potential of targeting TGFB3 in disease settings will find the TGFB3 Polyclonal Antibody (CAB8460) to be a valuable tool for their experiments. By providing reliable and consistent results, this antibody contributes to advancements in our understanding of TGFB3 biology and the development of novel treatment strategies for conditions affected by dysregulated TGF-β signaling.
Product Name:
TGFB3 Rabbit Polyclonal Antibody
SKU:
CAB8460
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human TGFB3 (NP_003230.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1.
Purification Method:
Affinity purification
Gene ID:
7043
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TGFB3 Rabbit pAb (CAB8460) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
