The TGFB2 Polyclonal Antibody (CAB3640) is a valuable tool for researchers studying TGFB2, a key protein involved in cell growth and differentiation, immune response regulation, and tissue repair. This antibody, raised in rabbits, is highly specific and reacts with human samples, making it ideal for use in Western blotting and other immunological assays.TGFB2, also known as transforming growth factor beta 2, plays a crucial role in various biological processes, including embryogenesis, wound healing, and immune cell regulation. Dysregulation of TGFB2 signaling has been implicated in numerous diseases, including cancer, fibrosis, and autoimmune disorders, highlighting the importance of studying this protein in a research setting.
By using the TGFB2 Polyclonal Antibody, researchers can accurately detect and analyze TGFB2 expression in different cell types and tissues, providing valuable insights into its function and potential therapeutic targets. This antibody is a valuable tool for investigations in immunology, cancer biology, and developmental biology, offering a deeper understanding of TGFB2 biology and its implications in human health and disease.
Product Name:
TGFB2 Rabbit Polyclonal Antibody
SKU:
CAB3640
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human TGFB2 (NP_001129071.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing.
Purification Method:
Affinity purification
Gene ID:
7042
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TGFB2 antibody (CAB3640) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
