The TGFb2 Polyclonal Antibody (CAB16226) is a vital tool for researchers studying TGFb2, a key cytokine involved in cell growth, differentiation, and immune suppression. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting.TGFb2, a member of the transforming growth factor beta superfamily, plays a crucial role in regulating immune responses, inflammation, and tissue repair. Its dysregulation has been linked to various diseases, including cancer, fibrosis, and autoimmune disorders.
By targeting TGFb2 with this antibody, researchers can gain insights into its functions and potential therapeutic applications.With its high reactivity and specificity, the TGFb2 Polyclonal Antibody is an invaluable tool for investigators studying the complex roles of TGFb2 in health and disease. Whether exploring its role in cancer progression, tissue remodeling, or immune regulation, this antibody provides reliable and accurate detection of TGFb2 protein, enabling detailed analysis in a variety of research settings.
Product Name:
TGFB2 Rabbit Polyclonal Antibody
SKU:
CAB16226
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human TGFB2 (NP_001129071.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing.
Purification Method:
Affinity purification
Gene ID:
7042
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat liver using TGFB2 Rabbit pAb (CAB16226) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
