The TGFB1 Polyclonal Antibody is a powerful tool for researchers studying Transforming Growth Factor Beta 1 (TGFB1), a crucial cytokine involved in regulating cell growth, differentiation, and immune responses. This antibody, produced in rabbits, exhibits high specificity and sensitivity when used in Western blot applications with human samples. By targeting the TGFB1 protein, researchers can investigate its role in various biological processes, making it an essential tool for studies in immunology, cancer research, and developmental biology.
TGFB1 is a key player in modulating immune responses and promoting tissue repair, making it a potential target for therapeutic intervention in conditions such as cancer, fibrosis, and autoimmune diseases. Understanding the function of TGFB1 is essential for developing targeted therapies that can effectively modulate its activity to benefit patients. With the TGFB1 Polyclonal Antibody, researchers can delve deeper into the mechanisms of TGFB1 signaling and its impact on disease progression.
Product Name:
Tgfb1 Polyclonal Antibody
SKU:
CAB23262
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant protein of mouse Tgfb1.
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
Tgfb; Tgfb-1; TGFbeta1; TGF-beta1; Tgfb1
Positive Sample:
Mouse spleen,Rat spleen
Conjugate:
Unconjugated
Calculated MW:
44kDa
Observed MW:
44kDa
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer.
Purification Method:
Affinity purification
Gene ID:
21803
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Tgfb1 Rabbit pAb (CAB23262) at 1:2500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
