TGFB1 Rabbit Polyclonal Antibody (CAB2124)
- SKU:
- CAB2124
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | TGFB1 Rabbit Polyclonal Antibody |
SKU: | CAB2124 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 291-390 of human TGF beta 1 (NP_000651.3). |
Sequence: | KNCC VRQL YIDF RKDL GWKW IHEP KGYH ANFC LGPC PYIW SLDT QYSK VLAL YNQH NPGA SAAP CCVP QALE PLPI VYYV GRKP KVEQ LSNM IVRS CKCS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:200 |
Synonyms: | CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1; TGF beta 1 |
Positive Sample: | K-562,Mouse spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 44kDa |
Observed MW: | 12kDa/25kDa/45-60kDa |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Purification Method: | Affinity purification |
Gene ID: | 7040 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |