The TGFb1 Polyclonal Antibody (CAB2124) is a valuable tool for researchers studying TGFb1, a crucial cytokine involved in immune regulation and tissue development. Produced in rabbits, this antibody exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TGFb1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in immunology, cancer research, and tissue biology.TGFb1, a multifunctional growth factor, plays a pivotal role in diverse biological processes such as cell growth, differentiation, and immune regulation.
Its dysregulation has been implicated in various diseases including cancer, fibrosis, and autoimmune disorders. Understanding the mechanisms underlying TGFb1 signaling is crucial for developing targeted therapies and diagnostic tools for these conditions. With its high specificity and sensitivity, the TGFb1 Polyclonal Antibody (CAB2124) is a valuable asset for researchers aiming to unravel the complex functions of TGFb1 in health and disease.
Product Name:
TGFB1 Rabbit Polyclonal Antibody
SKU:
CAB2124
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 291-390 of human TGF beta 1 (NP_000651.3).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Purification Method:
Affinity purification
Gene ID:
7040
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TGF beta 1 Rabbit pAb (CAB2124) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
