The TGFB1 Polyclonal Antibody (CAB15103) is a vital tool for researchers studying TGFB1, a key player in immune regulation and cell growth. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TGFB1 protein, researchers can accurately detect and analyze its expression in various cell types, making it ideal for investigations in immunology, cancer research, and beyond.
TGFB1, also known as transforming growth factor beta 1, is a crucial regulator of immune responses and cell proliferation. Its involvement in inflammation, tissue repair, and cancer progression highlights its importance as a potential therapeutic target for various diseases. By deepening our understanding of TGFB1 activity, researchers can pave the way for innovative treatments that manipulate immune responses and cell growth in a controlled manner.
Product Name:
TGFB1 Rabbit Polyclonal Antibody
SKU:
CAB15103
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-280 of human TGF beta 1 (NP_000651.3).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Purification Method:
Affinity purification
Gene ID:
7040
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of NIH/3T3 cells using TGF beta 1 Rabbit pAb (CAB15103) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
