TGF beta Receptor II (TGFBR2) Monoclonal Antibody (CAB22471)
- SKU:
- CAB22471
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Frequently bought together:
Description
Product Name: | TGF beta Receptor II (TGFBR2) Monoclonal Antibody |
SKU: | CAB22471 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TGF beta Receptor II (TGFBR2) (NP_003233.4). |
Sequence: | TWET GKTR KLME FSEH CAII LEDD RSDI SSTC ANNI NHNT ELLP IELD TLVG KGRF AEVY KAKL KQNT SEQF ETVA VKIF PYEE YASW KTEK DIFS DINL K |
Tested Applications: | IHC-P ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 |
Synonyms: | AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; tbetaR-II; TGFbeta-RII; TGF beta Receptor II (TGFBR2) |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 65kDa |
Observed MW: | Refer to figures |
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Purification Method: | Affinity purification |
Gene ID: | 7048 |
Clone Number: | ARC57218 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |