TGF beta Receptor II (TGFBR2) Rabbit Monoclonal Antibody (CAB19124)
- SKU:
- CAB19124
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | TGF beta Receptor II (TGFBR2) Rabbit Monoclonal Antibody |
SKU: | CAB19124 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-130 of human TGF beta Receptor II (TGFBR2) (TGFBR2) (P37173). |
Sequence: | TIPP HVQK SVNN DMIV TDNN GAVK FPQL CKFC DVRF STCD NQKS CMSN CSIT SICE KPQE VCVA VWRK NDEN ITLE TVCH DPKL PYHD FILE DAAS PKCI MKEK KKPG |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; tbetaR-II; TGFbeta-RII; TGF beta Receptor II (TGFBR2) |
Positive Sample: | Hep G2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 65kDa/67kDa/9kDa |
Observed MW: | 70-80kDa,90kDa |
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Purification Method: | Affinity purification |
Gene ID: | 7048 |
Clone Number: | ARC0407 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |