The TGDS Polyclonal Antibody (PACO50058) is a valuable tool for research involving TGDS, a protein involved in various biological processes such as cell adhesion and migration. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TGDS protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in cell biology and disease research.
TGDS, also known as Tissue-type Plasminogen Activator, is a key player in cellular functions related to tissue repair and remodeling. Its role in cell adhesion and migration makes it a promising target for research focused on understanding processes like wound healing and cancer metastasis. By investigating the function of TGDS, researchers can gain insights into the mechanisms underlying these biological processes and potentially identify new therapeutic targets for various diseases.
Western Blot. Positive WB detected in: Rat liver tissue. All lanes: TGDS antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 41 kDa. Observed band size: 41 kDa..
Immunohistochemistry of paraffin-embedded human glioma using PACO50058 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human liver cancer using PACO50058 at dilution of 1:100.
TGDS: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily.Protein type: EC 4.2.1.46; LyaseChromosomal Location of Human Ortholog: 13q32.1Molecular Function: coenzyme binding; dTDP-glucose 4,6-dehydratase activityBiological Process: nucleotide-sugar metabolic processDisease: Catel-manzke Syndrome
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
