Thyroglobulin Rabbit Polyclonal Antibody (CAB11708)
- SKU:
- CAB11708
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | Thyroglobulin Rabbit Polyclonal Antibody |
SKU: | CAB11708 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 365-540 of human Thyroglobulin (NP_003226.4). |
Sequence: | ASER QQAL SRLY FGTS GYFS QHDL FSSP EKRW ASPR VARF ATSC PPTI KELF VDSG LLRP MVEG QSQQ FSVS ENLL KEAI RAIF PSRG LARL ALQF TTNP KRLQ QNLF GGKF LVNV GQFN LSGA LGTR GTFN FSQF FQQL GLAS FLNG GRQE DLAK PLSV GLDS NSST GTPE AAKK |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | TGN; AITD3; Thyroglobulin |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 305kDa |
Observed MW: | 290kDa |
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
Purification Method: | Affinity purification |
Gene ID: | 7038 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |