The TFRC Polyclonal Antibody (CAB5865) is a versatile tool for researchers studying Transferrin Receptor (TFRC), a key protein involved in cellular iron uptake and metabolism. This antibody, generated through immunization of rabbits, exhibits high specificity and sensitivity towards TFRC in human samples and is validated for use in Western blot assays.TFRC is crucial for maintaining iron homeostasis in cells and is commonly dysregulated in various diseases, including cancer, anemia, and neurodegenerative disorders. By targeting TFRC with this polyclonal antibody, researchers can accurately detect and quantify TFRC levels in different cell types, allowing for detailed investigations into the role of iron metabolism in health and disease.
The TFRC Polyclonal Antibody (CAB5865) opens up possibilities for exploring the mechanisms underlying iron regulation and its implications for physiological processes and pathological conditions. Its application holds promise for advancing knowledge in areas such as cancer biology, metabolic disorders, and neurodegeneration, paving the way for the development of novel therapeutic approaches targeting TFRC.
Product Name:
TFRC Rabbit Polyclonal Antibody
SKU:
CAB5865
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human CD71/Transferrin Receptor (NP_001121620.1).
Cell membrane, Melanosome, Secreted, Single-pass type II membrane protein.
Calculated MW:
85kDa
Observed MW:
90kDa
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified.
Purification Method:
Affinity purification
Gene ID:
7037
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD71/Transferrin Receptor Rabbit pAb (CAB5865) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
