The TFR2 Polyclonal Antibody (CAB9845) is a valuable tool for researchers studying the transferrin receptor 2 (TFR2) protein, which is involved in iron homeostasis and regulation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the TFR2 protein, this antibody allows for detection and analysis in a variety of cell types, making it ideal for investigations in the fields of biochemistry and cell biology.TFR2 plays a crucial role in iron metabolism, including the regulation of iron uptake and storage within cells.
Dysregulation of TFR2 has been implicated in various diseases, such as hereditary hemochromatosis and certain types of cancer. Therefore, studying the function and activity of TFR2 using this antibody can provide valuable insights into the underlying mechanisms of these conditions and potentially lead to the development of novel therapeutic strategies.Overall, the TFR2 Polyclonal Antibody (CAB9845) offers researchers a reliable tool for investigating the roles of TFR2 in iron homeostasis and disease pathogenesis, advancing our understanding of these complex biological processes.
Product Name:
TFR2 Rabbit Polyclonal Antibody
SKU:
CAB9845
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 130-330 of human TFR2 (NP_003218.2).
Cell membrane, Cytoplasm, Single-pass type II membrane protein.
Calculated MW:
89kDa
Observed MW:
100kDa
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
7036
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TFR2 Rabbit pAb (CAB9845) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
