The TFPI Rabbit Monoclonal Antibody (CAB8704) is a high-quality antibody specifically designed for research involving Tissue Factor Pathway Inhibitor (TFPI). TFPI is a vital regulator of blood clotting processes, playing a key role in maintaining hemostasis and preventing excessive clot formation. This monoclonal antibody, produced in rabbits, exhibits high reactivity with TFPI in human samples and is validated for use in various applications, including Western blotting. By binding to the TFPI protein, this antibody enables precise detection and analysis in a wide range of cell types, making it an essential tool for studies in hemostasis, thrombosis, and cardiovascular research.
TFPI's role as a natural anticoagulant makes it a crucial target for investigation in various health conditions, including coagulation disorders, cardiovascular diseases, and thrombotic disorders. Understanding the function and regulation of TFPI is essential for developing therapeutic strategies to manage these conditions effectively.In conclusion, the TFPI Rabbit Monoclonal Antibody (CAB8704) offers researchers a reliable and specific tool to study TFPI and its implications in blood clotting processes, providing valuable insights for advancing clinical and translational research in thrombosis-related disorders.
Product Name:
TFPI Rabbit Monoclonal Antibody
SKU:
CAB8704
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-304 of human TFPI (P10646).
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
Purification Method:
Affinity purification
Gene ID:
7035
Clone Number:
ARC1154
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of BxPC-3 cells, using TFPI Rabbit mAb (CAB8704) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
