The TFPI Polyclonal Antibody (CAB1624) is a valuable tool for researchers studying Tissue Factor Pathway Inhibitor (TFPI), a key regulator of blood coagulation. This antibody, produced in rabbits, has high specificity for human samples and is validated for use in various applications, including Western blotting.TFPI is a crucial protein in the coagulation cascade, acting to inhibit the tissue factor pathway and prevent excessive blood clot formation. Dysregulation of TFPI has been implicated in a variety of thrombotic disorders, making it a promising target for therapeutic interventions.
By binding specifically to TFPI, this antibody enables researchers to detect and analyze the protein in different cell types and tissues. Its versatility and reliability make it an essential tool for studies in hemostasis, thrombosis, and cardiovascular diseases. Researchers can use this antibody to further explore the role of TFPI in health and disease, ultimately advancing our understanding of blood clotting mechanisms and potential treatment strategies.
Product Name:
TFPI Rabbit Polyclonal Antibody
SKU:
CAB1624
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-224 of human TFPI (NP_001027452.1).
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
Purification Method:
Affinity purification
Gene ID:
7035
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TFPI antibody (CAB1624) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
