TFPI Rabbit Polyclonal Antibody (CAB12692)
- SKU:
- CAB12692
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
Product Name: | TFPI Rabbit Polyclonal Antibody |
SKU: | CAB12692 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-224 of human TFPI (NP_001027452.1). |
Sequence: | DSEE DEEH TIIT DTEL PPLK LMHS FCAF KADD GPCK AIMK RFFF NIFT RQCE EFIY GGCE GNQN RFES LEEC KKMC TRDN ANRI IKTT LQQE KPDF CFLE EDPG ICRG YITR YFYN NQTK QCER FKYG GCLG NMNN FETL EECK NICE DGPN GFQV DNYG TQLN AVNN SLTP QSTK VPSL FVTK EGTN DGWK NAAH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | EPI; TFI; LACI; TFPI1; TFPI |
Positive Sample: | MCF7,Mouse spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | GPI-anchor, Lipid-anchor, Microsome membrane, Secreted. |
Calculated MW: | 35kDa |
Observed MW: | 32kDa |
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
Purification Method: | Affinity purification |
Gene ID: | 7035 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |