The TFEB Polyclonal Antibody is a valuable tool for researchers studying the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting TFEB in a variety of cellular samples. Its validation for use in techniques such as Western blotting ensures reliable and accurate results in research focused on cellular homeostasis, metabolism, and autophagy regulation.TFEB is a key player in the cellular response to stress, nutrient availability, and energy balance, making it essential for maintaining cellular health and function.
Dysregulation of TFEB activity has been linked to various diseases, including neurodegenerative disorders, metabolic syndromes, and certain types of cancer. By studying TFEB expression and function with the TFEB Polyclonal Antibody, researchers can gain insights into the mechanisms underlying these diseases and identify potential therapeutic targets for intervention.
Product Name:
TFEB Polyclonal Antibody
SKU:
CAB21657
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 391-461 of human TFEB (NP_009093.1).
Enables DNA-binding transcription factor activity; enzyme binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to amino acid starvation; lysosome localization; and positive regulation of autophagy. Located in cytosol; lysosomal membrane; and nucleoplasm.
Purification Method:
Affinity purification
Gene ID:
7942
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TFEB Rabbit pAb (CAB21657) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
