The TFE3 Polyclonal Antibody (CAB0548) is a powerful tool for researchers studying the TFE3 protein, a transcription factor associated with various cellular processes, including cell proliferation, differentiation, and survival. This antibody, generated in rabbits, is highly specific to human samples and has been extensively validated for its use in immunofluorescence and immunohistochemistry applications.TFE3, a member of the microphthalmia (MiT) family of transcription factors, plays a crucial role in the regulation of gene expression involved in cell growth and development. Its dysregulation has been linked to various diseases, including cancer, metabolic disorders, and neurodegenerative diseases.
By targeting the TFE3 protein, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.With its high sensitivity and specificity, the TFE3 Polyclonal Antibody is a valuable tool for researchers investigating the role of TFE3 in various biological processes and diseases. Its versatility and reliability make it an essential component of any laboratory studying transcription factors and their impact on cellular function.
Product Name:
TFE3 Rabbit Monoclonal Antibody
SKU:
CAB0548
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 191-440 of human TFE3 (P19532).
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7030
Clone Number:
ARC1829
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TFE3 Rabbit mAb (CAB0548) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
