The TFDp3 Polyclonal Antibody (PAC053474) is a valuable tool for researchers studying TFDp3, a transcription factor that plays a key role in regulating gene expression. The antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting TFDp3 in human samples, making it an ideal choice for Western blot applications. By binding to TFDp3, this antibody enables researchers to analyze the expression and function of this important transcription factor in various cell types, providing insights into its role in gene regulation and its potential implications in disease processes.
TFDp3, also known as Transcription Factor Dp-3, is involved in the control of cell growth and differentiation, making it a critical player in development and disease. Its aberrant expression has been linked to cancer and other disorders, highlighting the importance of understanding its regulatory mechanisms. By studying TFDp3 using this antibody, researchers can further unravel its functions and potentially identify new therapeutic targets for conditions influenced by its activity.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO53474 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO53474 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.
Synonyms:
Transcription factor Dp family member 3 (Cancer/testis antigen 30) (CT30) (Hepatocellular carcinoma-associated antigen 661), TFDP3, DP4 HCA661
UniProt Protein Function:
TFDP3: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase. Belongs to the E2F/DP family.Protein type: DNA-binding; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xq26.2Cellular Component: cytoplasm; nucleusMolecular Function: protein heterodimerization activityBiological Process: G1/S transition of mitotic cell cycle; regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.[provided by RefSeq, May 2010]
