The TFAP4 Polyclonal Antibody (CAB16727) is a valuable tool for research involving TFAP4, a transcription factor that plays a crucial role in regulating gene expression and cellular processes. This antibody, generated in rabbits, is highly specific for detecting TFAP4 in human samples and has been validated for use in Western blot and immunohistochemistry applications.TFAP4, also known as transcription factor AP-4, is involved in the control of cell proliferation, differentiation, and apoptosis. Its dysregulation has been linked to various diseases, including cancer and neurological disorders. By targeting TFAP4, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify therapeutic targets for intervention.
This antibody provides researchers with a reliable tool for studying TFAP4 expression and function in different cell types and tissues. Its high specificity and sensitivity make it suitable for a range of experimental approaches, making it a valuable asset for studies in molecular biology, cancer research, and developmental biology. Unlocking the role of TFAP4 in disease pathogenesis may lead to the development of novel treatment strategies aimed at targeting this transcription factor.
Product Name:
[KO Validated] TFAP4 Rabbit Polyclonal Antibody
SKU:
CAB16727
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-338 of human TFAP4 (NP_003214.1).
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).
Purification Method:
Affinity purification
Gene ID:
7023
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] TFAP4 Rabbit pAb (CAB16727) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
