The TFAM Polyclonal Antibody (CAB1926) is a valuable tool for research involving TFAM, a mitochondrial transcription factor essential for mitochondrial DNA replication and maintenance. This antibody is raised in rabbits and is highly reactive with human samples, making it a reliable choice for various research applications.TFAM, also known as mitochondrial transcription factor A, plays a pivotal role in mitochondrial biogenesis and function by binding to mitochondrial DNA and regulating transcription. Its function is crucial for cellular energy production and metabolism, making it a key player in various physiological processes.The TFAM Polyclonal Antibody (CAB1926) enables the detection and analysis of TFAM in different cell types, providing valuable insights into mitochondrial function and dysfunction.
With its application in Western blotting, this antibody is ideal for studies in mitochondrial biology, metabolism, and related diseases.Understanding the role of TFAM in mitochondrial health is essential for unraveling the mechanisms underlying mitochondrial dysfunction and associated disorders, such as neurodegenerative diseases, metabolic disorders, and aging-related conditions. The TFAM Polyclonal Antibody (CAB1926) offers researchers a reliable tool to further investigate TFAM's functions and potential therapeutic implications.
Product Name:
TFAM Polyclonal Antibody
SKU:
CAB1926
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TFAM (NP_003192.1).
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7019
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TFAM antibody (CAB1926) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
