The TFAM Polyclonal Antibody (CAB13552) is a vital tool for researchers studying mitochondrial transcription factor A (TFAM), a key protein involved in regulating mitochondrial DNA replication and transcription. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By targeting TFAM, researchers can better understand its role in mitochondrial biogenesis, energy metabolism, and cellular function.TFAM is essential for maintaining mitochondrial DNA integrity and promoting mitochondrial gene expression, making it a crucial player in cellular energy production and overall metabolic health.
Dysregulation of TFAM has been linked to various diseases, including neurodegeneration and metabolic disorders. As such, studying TFAM with this antibody may provide insights into the pathogenesis of these conditions and inform potential therapeutic strategies aimed at restoring mitochondrial function.Overall, the TFAM Polyclonal Antibody (CAB13552) is a valuable asset for researchers investigating the role of TFAM in mitochondrial biology and its implications for human health. Its versatility and reliability make it a valuable tool for advancing our understanding of mitochondrial function and the development of targeted therapies for associated disorders.
Product Name:
TFAM Rabbit Polyclonal Antibody
SKU:
CAB13552
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TFAM (NP_003192.1).
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7019
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TFAM Rabbit pAb (CAB13552) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
