Tf Antibody (PACO63863)
- SKU:
- PACO63863
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Tf Antibody (PACO63863)
The TF Polyclonal Antibody (PACO63863) is a valuable tool for researchers studying TF, a key protein involved in various biological processes. This antibody, produced through immunization of rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By targeting the TF protein, this antibody enables the detection and analysis of TF expression in different cell types, facilitating research in fields such as immunology, oncology, and cardiovascular health.TF, also known as Tissue Factor, is a transmembrane glycoprotein that plays a crucial role in the initiation of blood coagulation. Additionally, TF has been implicated in various physiological and pathological processes, including inflammation, angiogenesis, and metastasis.
Understanding the functions and regulation of TF is essential for unraveling its role in diseases such as cancer, thrombosis, and cardiovascular disorders, offering potential targets for therapeutic intervention.In conclusion, the TF Polyclonal Antibody (PACO63863) serves as a valuable tool for investigating the intricate functions of TF in health and disease. Its versatility and reliability make it an essential component of research projects aimed at elucidating the complex roles of TF in various biological pathways.
| Antibody Name: | Tf Antibody (PACO63863) |
| Antibody SKU: | PACO63863 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Serotransferrin protein (401-697AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO63863 diluted at 1:400 and staining in paraffin-embedded mouse liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. |
| Synonyms: | Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin), Tf, Trf |
| UniProt Protein Function: | TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; basement membrane; vesicle; endosome Molecular Function:protein binding; ferric iron binding; metal ion binding; ferric iron transmembrane transporter activity Biological Process: positive regulation of myelination; iron ion homeostasis; transport; positive regulation of transcription, DNA-dependent; actin filament organization; positive regulation of bone resorption; ion transport; osteoclast differentiation; ferric iron transport; iron ion transport; activation of JNK activity; positive regulation of phosphorylation |
| UniProt Code: | Q921I1 |
| NCBI GenInfo Identifier: | 20330802 |
| NCBI Gene ID: | 22041 |
| NCBI Accession: | NP_598738.1 |
| UniProt Secondary Accession: | Q921I1,O35421, Q3UBW7, Q58E69, Q61803, Q62357, Q62358 Q62359, Q63915, Q64515, Q8VII5, Q922C0, |
| UniProt Related Accession: | Q921I1 |
| Molecular Weight: | 80.0 kDa |
| NCBI Full Name: | serotransferrin |
| NCBI Synonym Full Names: | transferrin |
| NCBI Official Symbol: | Trf  |
| NCBI Official Synonym Symbols: | HP; Tf; Tfn; hpx; Cd176; AI266983Â Â |
| NCBI Protein Information: | serotransferrin |
| UniProt Protein Name: | Serotransferrin |
| UniProt Synonym Protein Names: | Beta-1 metal-binding globulin; Siderophilin |
| UniProt Gene Name: | Tf  |
| UniProt Entry Name: | TRFE_MOUSE |
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