Anti-TSPAN4 Antibody (CAB10253)
- SKU:
- CAB10253
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-TSPAN4 Antibody (CAB10253)
The Tetraspanin-4 Polyclonal Antibody (CAB10253) is a valuable tool for researchers studying Tetraspanin-4, a membrane protein involved in cell adhesion and signaling processes. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to Tetraspanin-4, this antibody allows for precise detection and analysis in a variety of cell types.Tetraspanin-4 plays a key role in cell-cell interactions and is implicated in various physiological and pathological processes, making it a promising target for research in areas such as cancer biology, developmental biology, and immune response regulation.
Understanding the functions and regulation of Tetraspanin-4 is essential for advancing our knowledge of cell biology and potentially identifying new therapeutic strategies for diseases where this protein is involved.
| Antibody Name: | Anti-TSPAN4 Antibody |
| Antibody SKU: | CAB10253 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 107-201 of human TSPAN4 (NP_003262.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse kidney, Mouse lung, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 107-201 of human TSPAN4 (NP_003262.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YTDK IDRY AQQD LKKG LHLY GTQG NVGL TNAW SIIQ TDFR CCGV SNYT DWFE VYNA TRVP DSCC LEFS ESCG LHAP GTWW KAPC YETV KVWL QEN |
| Gene ID: | 7106 |
| Uniprot: | O14817 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 26kDa |
| Observed MW: | 26kDa |
| Synonyms: | TSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4 |
| Background: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | TSPAN4: is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane; vesicle Molecular Function:antigen binding; integrin binding; protein binding Biological Process: cell surface receptor linked signal transduction; protein complex assembly |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14817 |
| NCBI GenInfo Identifier: | 3183082 |
| NCBI Gene ID: | 7106 |
| NCBI Accession: | O14817.1 |
| UniProt Secondary Accession: | O14817,Q6IAP6, |
| UniProt Related Accession: | O14817 |
| Molecular Weight: | 26kDa |
| NCBI Full Name: | Tetraspanin-4 |
| NCBI Synonym Full Names: | tetraspanin 4 |
| NCBI Official Symbol: | TSPAN4Â Â |
| NCBI Official Synonym Symbols: | NAG2; NAG-2; TM4SF7; TSPAN-4; TETRASPANÂ Â |
| NCBI Protein Information: | tetraspanin-4 |
| UniProt Protein Name: | Tetraspanin-4 |
| UniProt Synonym Protein Names: | Novel antigen 2; NAG-2; Transmembrane 4 superfamily member 7 |
| UniProt Gene Name: | TSPAN4Â Â |
 | Western blot analysis of extracts of various cell lines, using TSPAN4 antibody (CAB10253) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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