The TET2 Polyclonal Antibody (CAB17306) is a key tool for researchers studying TET2, a critical enzyme involved in DNA demethylation and gene regulation. This antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By specifically binding to TET2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in epigenetics, cancer biology, and stem cell research.TET2 plays a crucial role in regulating DNA methylation patterns, which are essential for normal cellular function and development.
Dysregulation of TET2 has been implicated in a range of diseases, including leukemia, myelodysplastic syndromes, and cardiovascular disorders. Understanding the function of TET2 and its impact on gene expression is vital for uncovering potential therapeutic targets and strategies for these conditions.Overall, the TET2 Polyclonal Antibody (CAB17306) provides researchers with a powerful tool for investigating the role of TET2 in various biological processes and disease states, ultimately advancing our understanding of epigenetic mechanisms and their implications for human health.
Product Name:
TET2 Rabbit Polyclonal Antibody
SKU:
CAB17306
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of TET2 (NP_001120680.1).
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
54790
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TET2 Rabbit pAb (CAB17306) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
