The TET2 Polyclonal Antibody (CAB1526) is a valuable tool for researchers studying TET2, a key epigenetic regulator involved in DNA demethylation and gene expression. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting TET2 in human samples, making it a reliable choice for Western blot applications.TET2 is crucial for maintaining normal hematopoiesis and has been implicated in various hematologic malignancies, including leukemia and myelodysplastic syndromes.
By targeting TET2, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets.With its ability to specifically bind to TET2, this polyclonal antibody enables researchers to accurately analyze TET2 expression and activity in different cell types and experimental conditions. Its versatility and reliability make it an indispensable tool for advancing research in the fields of epigenetics, cancer biology, and hematopoiesis.
Product Name:
TET2 Rabbit Polyclonal Antibody
SKU:
CAB1526
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1833-2002 of human TET2 (NP_001120680.1).
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
54790
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using TET2 Rabbit pAb (CAB1526) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
