The TET2 Polyclonal Antibody (CAB12779) is a valuable tool for researchers studying TET2, a key enzyme involved in DNA demethylation and gene regulation. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By binding to TET2 protein, it allows for accurate detection and analysis in various cell types, making it ideal for studies in epigenetics, cancer research, and stem cell biology.
TET2 is known for its role in maintaining DNA methylation patterns and gene expression, making it a crucial player in both normal development and disease processes. Dysregulation of TET2 has been implicated in various cancers, leukemia, and other disorders, highlighting its potential as a therapeutic target. By understanding the function of TET2, researchers can uncover novel mechanisms of disease and develop targeted therapies for these conditions.
Product Name:
TET2 Rabbit Polyclonal Antibody
SKU:
CAB12779
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1833-2002 of human TET2 (NP_001120680.1).
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
54790
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse heart, using TET2 antibody (CAB12779) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
