The TESPA1 Antibody (PAC027785) is a valuable tool for researchers studying TESPA1, a protein involved in cell adhesion and signaling pathways. This polyclonal antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunohistochemistry applications.TESPA1 is known to play a role in cell migration and invasion, making it a potential target in cancer research and metastasis studies.
By using this antibody, researchers can detect and analyze TESPA1 expression in various cell types, providing insights into its function and potential therapeutic implications.With its high reactivity and specificity, the TESPA1 Antibody is a reliable tool for investigating the role of TESPA1 in cellular processes and disease pathways. Its versatility and accuracy make it an essential component for immunology and cancer research projects.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO27785 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO27785 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.
Synonyms:
Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1), TESPA1, KIAA0748
UniProt Protein Function:
TESPA1: Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12q13.2Cellular Component: signalosome; endoplasmic reticulum membrane; cytoplasmMolecular Function: receptor bindingBiological Process: positive regulation of T cell differentiation in the thymus; positive regulation of T cell receptor signaling pathway; signalosome assembly
