The TERT Polyclonal Antibody (CAB16625) is a valuable tool for researchers studying the telomerase reverse transcriptase (TERT) protein, an enzyme essential for maintaining telomere length and cellular aging processes. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for a wide range of research applications, including Western blot analysis.TERT plays a crucial role in cellular function by preventing chromosomal instability and promoting cell proliferation. Dysregulation of TERT has also been linked to various age-related diseases and cancer development.
Therefore, studying the expression and activity of TERT using the CAB16625 antibody can provide important insights into telomerase function and its implications in disease progression.By targeting the TERT protein, researchers can explore potential therapeutic strategies for diseases associated with telomere dysfunction, such as cancer, aging-related disorders, and genetic syndromes. The CAB16625 antibody offers a reliable tool for investigating TERT biology and its impact on cellular processes, making it an essential asset for studies in molecular biology and cancer research.
Product Name:
TERT Rabbit Polyclonal Antibody
SKU:
CAB16625
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1050-1132 of human TERT (NP_937983.2).
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Purification Method:
Affinity purification
Gene ID:
7015
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human breast cancer using TERT Rabbit pAb (CAB16625) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
