The TERF2IP Polyclonal Antibody (CAB15163) is a valuable tool for researchers studying TERF2IP, a protein involved in telomere maintenance and DNA repair processes. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the TERF2IP protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for studies in molecular biology, genetics, and cancer research.TERF2IP, also known as shelterin complex subunit TINF2, plays a crucial role in protecting telomeres and maintaining genomic stability.
Dysregulation of TERF2IP has been implicated in telomere dysfunction, which is associated with aging, cancer, and genetic disorders. Research on TERF2IP is key to understanding the mechanisms of telomere maintenance and the impact of telomere dysfunction on cellular health.By utilizing the TERF2IP Polyclonal Antibody, researchers can further explore the functions and interactions of TERF2IP in various cellular processes, ultimately contributing to the development of targeted therapies for telomere-related diseases and disorders.
Product Name:
TERF2IP Rabbit Polyclonal Antibody
SKU:
CAB15163
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TERF2IP (NP_061848.2).
Enables G-rich strand telomeric DNA binding activity and phosphatase binding activity. Involved in several processes, including positive regulation of NIK/NF-kappaB signaling; regulation of nucleobase-containing compound metabolic process; and regulation of protein modification process. Located in chromosome, telomeric region; cytosol; and nuclear body. Part of shelterin complex.
Purification Method:
Affinity purification
Gene ID:
54386
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TERF2IP Rabbit pAb (CAB15163) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
