The TERF2 Polyclonal Antibody (CAB16316) is a vital tool for researchers studying the telomeric repeat-binding factor 2 (TERF2) protein. This antibody, produced in rabbits, has been rigorously validated for use in Western blotting and immunofluorescence applications. By specifically recognizing the TERF2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential asset for studies in telomere biology and aging research.TERF2 is a key player in maintaining telomere stability and regulating telomere length, thus playing a crucial role in cellular senescence and genome integrity.
Dysregulation of TERF2 has been implicated in various age-related diseases, such as cancer and premature aging syndromes. Investigating the functions and mechanisms of TERF2 is essential for unveiling its potential as a therapeutic target for age-related disorders.By utilizing the TERF2 Polyclonal Antibody (CAB16316), researchers can gain deeper insights into the intricate roles of TERF2 in cellular aging and disease progression. This antibody's high specificity and sensitivity make it an invaluable tool for revealing the molecular mechanisms underlying telomere biology and advancing the field of aging research.
Product Name:
TERF2 Rabbit Polyclonal Antibody
SKU:
CAB16316
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TERF2 (NP_005643.2).
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Purification Method:
Affinity purification
Gene ID:
7014
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TERF2 Rabbit pAb (CAB16316) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
