The TERF1 Polyclonal Antibody (CAB0137) is a valuable tool for researchers studying the telomeric repeat binding factor 1 (TERF1) protein, which plays a crucial role in telomere maintenance and regulation. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot applications, enabling accurate detection and analysis of TERF1 protein levels in various cell types.TERF1 is a key player in telomere protection and DNA replication, making it a promising target for research in telomere biology, aging, and cancer studies.
By understanding the functions and mechanisms of TERF1, researchers can gain insights into the role of telomeres in cellular senescence, genome stability, and potentially uncover new therapeutic targets for diseases such as cancer and age-related disorders.The TERF1 Polyclonal Antibody (CAB0137) offers high sensitivity and specificity, making it an essential tool for investigators looking to explore the intricate workings of telomere biology and the role of TERF1 in various physiological and pathological processes.
Product Name:
TERF1 Rabbit Polyclonal Antibody
SKU:
CAB0137
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 52-275 of human TERF1 (NP_059523.2).
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Multiple transcripts of this gene are alternatively spliced products.
Purification Method:
Affinity purification
Gene ID:
7013
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TERF1 Rabbit pAb (CAB0137) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
