The TERB1 Polyclonal Antibody (PAC038298) is a vital tool for researchers studying telomere biology and DNA replication processes. This antibody is produced in rabbits and has been shown to exhibit high reactivity with human samples. Validated for use in Western blot applications, this antibody specifically binds to the TERB1 protein, enabling accurate detection and analysis in various cell types.TERB1, a crucial component of the meiotic telomere complex, plays a significant role in the maintenance of chromosome ends during cell division.
Understanding the function and regulation of TERB1 is essential for furthering our knowledge of telomere dynamics and DNA replication, which have implications in aging, cancer, and genetic disorders. Researchers interested in unraveling the complexities of telomere biology will find the TERB1 Polyclonal Antibody to be an invaluable resource for their studies.
Antibody Name:
TERB1 Antibody (PACO38298)
Antibody SKU:
PACO38298
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Telomere repeats-binding bouquet formation protein 1 protein (301-550AA)
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO38298 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO38298 at dilution of 1:100.
Background:
Meiosis-specific telomere-associated protein involved in meiotic telomere clustering, also named bouquet formation, the telomere-mediated chromosomal movement along the nuclear envelope which is crucial for homologous pairing and synapsis. Probably acts as a hub for the assembly of a conserved meiotic telomere complex required for chromosome movements via interaction with TERF1. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.
Synonyms:
Telomere repeats-binding bouquet formation protein 1 (Coiled-coil domain-containing protein 79), TERB1, CCDC79
