The Telethonin Polyclonal Antibody (CAB6765) offered by AssayGenie is a valuable tool for researchers studying Telethonin, a crucial protein involved in muscle contraction and maintenance. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the Telethonin protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it a versatile tool for studies in muscle biology and related fields.Telethonin, also known as T-cap or TCAP, is essential for the proper functioning of sarcomeres in muscle cells, contributing to muscle strength and integrity.
Mutations in the Telethonin gene have been linked to various muscle disorders, making it an important target for research in muscular dystrophies and related conditions. Understanding the role of Telethonin in muscle function is crucial for developing novel therapies to treat muscle diseases and improve patient outcomes.Overall, the Telethonin Polyclonal Antibody (CAB6765) from AssayGenie provides researchers with a reliable and accurate tool for investigating the role of Telethonin in muscle biology, with potential implications for the diagnosis and treatment of muscle-related disorders.
Product Name:
TCAP Rabbit Polyclonal Antibody
SKU:
CAB6765
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human TCAP (NP_003664.1).
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.
Purification Method:
Affinity purification
Gene ID:
8557
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with TCAP using TCAP Rabbit pAb (CAB6765) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
