The TEK Polyclonal Antibody (CAB0743) is a valuable tool for researchers studying the TEK protein, a receptor involved in angiogenesis and vascular development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the TEK protein, this antibody enables accurate detection and analysis in various cell types, making it an essential component for studies in vascular biology and cancer research.The TEK receptor, also known as TIE-2, plays a crucial role in regulating angiogenesis, the process of forming new blood vessels from existing ones.
Dysregulation of TEK signaling has been implicated in various diseases, including cancer, cardiovascular disorders, and inflammatory conditions. By understanding the mechanisms of TEK activation and function, researchers can potentially develop novel therapies targeting angiogenesis and vascular abnormalities in these pathological conditions.Overall, the TEK Polyclonal Antibody (CAB0743) serves as a valuable tool for investigating the role of TEK in health and disease, offering researchers a precise and reliable method for studying the complex functions of this important receptor in various biological contexts.
Product Name:
TEK Rabbit Polyclonal Antibody
SKU:
CAB0743
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 500-750 of human TEK (NP_000450.2).
Cell junction, Cell membrane, Cytoplasm, Secreted, Single-pass type I membrane protein, cytoskeleton, focal adhesion.
Calculated MW:
126kDa
Observed MW:
150kDa
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
7010
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HUVEC cells, using TEK Rabbit pAb (CAB0743) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
