TEF Antibody (PACO53442)
- SKU:
- PACO53442
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
TEF Antibody (PACO53442)
The TEF Antibody (PAC053442) is a polyclonal antibody designed for research involving TEF, a transcription factor that plays a critical role in gene regulation and cellular processes. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunohistochemistry applications. TEF is known to be involved in various biological pathways, including cell proliferation, differentiation, and apoptosis. Research has shown that dysregulation of TEF expression can lead to abnormal cell growth and development, making it a potential target for studies in cancer and other diseases.
By targeting the TEF protein, researchers can gain insights into the mechanisms underlying gene expression and cellular function, ultimately leading to a better understanding of disease processes and potential therapeutic interventions. The TEF Antibody is a valuable tool for scientists conducting research in molecular biology, cancer biology, and other related fields.
| Antibody Name: | TEF Antibody (PACO53442) |
| Antibody SKU: | PACO53442 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Thyrotroph embryonic factor protein (7-303AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: U87 whole cell lysate. All lanes: TEF antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 34, 31 kDa. Observed band size: 34 kDa. |
| Background: | Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'. |
| Synonyms: | Thyrotroph embryonic factor, TEF, KIAA1655 |
| UniProt Protein Function: | TEF: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3'. Belongs to the bZIP family. PAR subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: nucleus Molecular Function:double-stranded DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; rhythmic process; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q10587 |
| NCBI GenInfo Identifier: | 51338730 |
| NCBI Gene ID: | 7008 |
| NCBI Accession: | Q10587.3 |
| UniProt Secondary Accession: | Q10587,Q15729, Q7Z3J7, Q8IU94, Q96TG4, B0QYS8, B2RC22 |
| UniProt Related Accession: | Q10587 |
| Molecular Weight: | 30,635 Da |
| NCBI Full Name: | Thyrotroph embryonic factor |
| NCBI Synonym Full Names: | thyrotrophic embryonic factor |
| NCBI Official Symbol: | TEFÂ Â |
| NCBI Protein Information: | thyrotroph embryonic factor |
| UniProt Protein Name: | Thyrotroph embryonic factor |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TEFÂ Â |
| UniProt Entry Name: | TEF_HUMAN |
| Antibodies | ELISA Kits |
| TEF Antibody (PACO01603) | Human TEF (Thyrotroph Embryonic Factor) ELISA Kit (HUES02226) |
| TEF Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
TEF Antibody (PACO01603)
TEF Colorimetric Cell-Based ELISA
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