The TECTB Polyclonal Antibody (PAC061129) is a valuable tool for researching TECTB, a protein involved in various cellular processes. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TECTB protein, this antibody allows for the detection and analysis of TECTB in different cell types, making it an ideal choice for studies in molecular biology and cancer research.TECTB is known to play a role in cell growth, differentiation, and apoptosis, making it a key target for research in cancer biology and other related fields.
Understanding the function of TECTB is essential for uncovering its role in disease pathogenesis and identifying potential therapeutic strategies. By using the TECTB Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying TECTB-mediated cellular processes and develop novel approaches for targeting TECTB in disease intervention.
Antibody Name:
TECTB Antibody (PACO61129)
Antibody SKU:
PACO61129
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Beta-tectorin protein (18-118AA)
Immunofluorescence staining of HepG2 cells with PACO61129 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Synonyms:
Beta-tectorin, TECTB
UniProt Protein Function:
TECTB: One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.Protein type: Membrane protein, GPI anchorChromosomal Location of Human Ortholog: 10q25.2Cellular Component: extracellular region; plasma membrane; proteinaceous extracellular matrixMolecular Function: extracellular matrix structural constituentBiological Process: C-terminal protein lipidation
UniProt Protein Details:
NCBI Summary:
This gene encodes a non-collagenous glycoprotein component of the tectorial membrane, which covers the auditory hair cells in the cochlea of the inner ear. A similar protein in mouse functions in low-frequency hearing. [provided by RefSeq, Jul 2013]
