The TECPR2 Polyclonal Antibody (PAC049058) is a valuable tool for researchers studying the TECPR2 protein, which plays a key role in autophagy and protein trafficking within cells. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to TECPR2, researchers can detect and analyze this important protein in various cell types, making it an essential tool for studies in cell biology and autophagy research.TECPR2 is a crucial player in the autophagy pathway, a cellular process that degrades and recycles damaged proteins and organelles to maintain cell health.
Dysregulation of autophagy has been linked to various diseases, including neurodegenerative disorders and cancer. Therefore, understanding the function of TECPR2 is essential for uncovering the underlying mechanisms of these conditions and potentially identifying new therapeutic targets.With its ability to detect TECPR2 in different cellular contexts, the TECPR2 Polyclonal Antibody (PAC049058) provides researchers with a powerful tool to advance their understanding of autophagy and its implications in human health and disease.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO49058 at dilution of 1:100.
Immunofluorescent analysis of PC-3 cells using PACO49058 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Probably plays a role as positive regulator of autophagy.
Synonyms:
Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297), TECPR2, KIAA0297 KIAA0329
UniProt Protein Function:
TECPR2: Belongs to the WD repeat KIAA0329 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 14q32.31Molecular Function: protein bindingDisease: Spastic Paraplegia 49, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
