The TECPR1 Polyclonal Antibody (PAC046730) is a valuable tool for researchers studying TECPR1, a protein involved in autophagy and cellular homeostasis. This antibody is polyclonal, raised in rabbits, and has been validated for use in various applications, including Western blot and immunofluorescence.TECPR1 is a key player in the autophagy pathway, responsible for recycling cellular components and maintaining cellular health. Dysregulation of autophagy has been implicated in various diseases, including neurodegenerative disorders, cancer, and metabolic conditions.
By targeting TECPR1, researchers can better understand its role in these diseases and potentially develop new therapeutic strategies.This antibody binds specifically to TECPR1, allowing for precise detection and analysis in different cell types and experimental settings. Its high reactivity with human samples makes it a reliable tool for studies in cell biology, molecular biology, and disease research. By investigating the function of TECPR1, researchers can gain insight into autophagy mechanisms and potentially uncover new targets for therapeutic intervention.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO46730 at dilution of 1:100.
Immunofluorescent analysis of A375 cells using PACO46730 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
Synonyms:
Tectonin beta-propeller repeat-containing protein 1, TECPR1, KIAA1358
UniProt Protein Function:
TECPR1: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex. Belongs to the TECPR1 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Autophagy; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7q21.3Cellular Component: lysosomal membraneMolecular Function: phosphatidylinositol 3-phosphate binding; protein bindingBiological Process: autophagy
UniProt Protein Details:
NCBI Summary:
This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]
