UniProt Protein Function: | TECPR1: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex. Belongs to the TECPR1 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Autophagy; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7q21.3Cellular Component: lysosomal membraneMolecular Function: phosphatidylinositol 3-phosphate binding; protein bindingBiological Process: autophagy |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012] |
UniProt Code: | Q7Z6L1 |
NCBI GenInfo Identifier: | 74738829 |
NCBI Gene ID: | 25851 |
NCBI Accession: | Q7Z6L1.1 |
UniProt Secondary Accession: | Q7Z6L1,Q96EB0, Q9P2I9, Q9UFR6, A8KAD1, B3KPZ1, C9J024 F5GX57 |
UniProt Related Accession: | Q7Z6L1 |
Molecular Weight: | 129,854 Da |
NCBI Full Name: | Tectonin beta-propeller repeat-containing protein 1 |
NCBI Synonym Full Names: | tectonin beta-propeller repeat containing 1 |
NCBI Official Symbol: | TECPR1Â Â |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | tectonin beta-propeller repeat-containing protein 1 |
UniProt Protein Name: | Tectonin beta-propeller repeat-containing protein 1 |
UniProt Synonym Protein Names: | |
Protein Family: | Tectonin beta-propeller repeat-containing protein |
UniProt Gene Name: | TECPR1Â Â |
UniProt Entry Name: | TCPR1_HUMAN |