Anti-TEAD2 Antibody (CAB15594)
- SKU:
- CAB15594
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Anti-TEAD2 Antibody (CAB15594)
The TEAD2 Polyclonal Antibody (CAB15594) is a valuable tool for researchers studying TEAD2, a transcription factor known for its role in gene regulation and cell proliferation. This antibody, derived from rabbit serum, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.TEAD2, a member of the TEAD family of transcription factors, plays a crucial role in controlling the expression of genes involved in cell growth and differentiation. It is particularly important in the regulation of processes such as cell cycle progression and tissue development. By binding specifically to TEAD2, this antibody enables researchers to detect and study the protein in various cell types, providing valuable insights into its function.
The TEAD2 Polyclonal Antibody is an essential tool for investigations in the fields of developmental biology, cancer research, and stem cell biology. Understanding the mechanisms by which TEAD2 regulates gene expression and cellular processes is vital for uncovering new therapeutic targets and treatment strategies for a variety of diseases. Researchers can rely on this antibody to enhance their studies and broaden their understanding of TEAD2's role in health and disease.
| Antibody Name: | Anti-TEAD2 Antibody |
| Antibody SKU: | CAB15594 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TEAD2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-431 |
| Immunogen: | Recombinant protein of human TEAD2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8463 |
| Uniprot: | Q15562 |
| Cellular Location: | |
| Calculated MW: | 35kDa/49kDa |
| Observed MW: | 51KDa |
| Synonyms: | TEAD2, ETF, TEAD-2, TEF-4, TEF4 |
| Background: |
| UniProt Protein Function: | TEAD2: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: nucleoplasm Molecular Function:protein binding; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter |
| UniProt Code: | Q15562 |
| NCBI GenInfo Identifier: | 21264529 |
| NCBI Gene ID: | 8463 |
| NCBI Accession: | Q15562.2 |
| UniProt Secondary Accession: | Q15562,Q8NA25, Q96IG3, B4DTJ6, M0R1T9, |
| UniProt Related Accession: | Q15562 |
| Molecular Weight: | 49,640 Da |
| NCBI Full Name: | Transcriptional enhancer factor TEF-4 |
| NCBI Synonym Full Names: | TEA domain transcription factor 2 |
| NCBI Official Symbol: | TEAD2Â Â |
| NCBI Official Synonym Symbols: | ETF; TEF4; TEF-4; TEAD-2Â Â |
| NCBI Protein Information: | transcriptional enhancer factor TEF-4 |
| UniProt Protein Name: | Transcriptional enhancer factor TEF-4 |
| UniProt Synonym Protein Names: | TEA domain family member 2; TEAD-2 |
| Protein Family: | Transcriptional enhancer factor |
| UniProt Gene Name: | TEAD2Â Â |
| UniProt Entry Name: | TEAD2_HUMAN |
 | Western blot analysis of extracts of A-431 cells, using HSPB7 antibody (CAB15594) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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