The TEAD1/2/3/4 Rabbit Monoclonal Antibody (CAB5092) is a highly specific antibody designed for research focused on TEAD1, TEAD2, TEAD3, and TEAD4 proteins involved in transcriptional regulation and cell proliferation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as Western blot and immunohistochemistry.The TEAD family of transcription factors are key regulators of gene expression and play a crucial role in various cellular processes, including cell growth, differentiation, and development. By targeting TEAD1, TEAD2, TEAD3, and TEAD4, researchers can gain insights into their functions in different cell types and biological contexts, making this antibody an essential tool for studies in molecular biology and cancer research.
Understanding the role of TEAD proteins in transcriptional regulation is essential for unraveling the mechanisms underlying diseases such as cancer, where dysregulation of gene expression can drive tumorigenesis. The TEAD1/2/3/4 Rabbit Monoclonal Antibody provides researchers with a reliable tool for investigating the functions of these important transcription factors and their potential implications in disease pathology.
Product Name:
TEAD1 Rabbit Monoclonal Antibody
SKU:
CAB5092
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 174-263 of human TEAD4 (NP_003204.2)
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified.
Purification Method:
Affinity purification
Gene ID:
7003/ 7004/ 8463/ 7005
Clone Number:
ARC1158
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with TEAD2 using TEAD1/2/3/4 mAb(CAB5092) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 20s.
