The TDP43 Rabbit Monoclonal Antibody (CAB19123) is specifically designed for research involving TDP43, a protein known for its role in RNA processing and neurodegenerative diseases such as ALS and frontotemporal lobar degeneration. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blotting and immunofluorescence staining.TDP43 is a key player in RNA metabolism and has been implicated in the pathogenesis of neurodegenerative disorders. By targeting TDP43 with this antibody, researchers can analyze its expression, localization, and function in different cell types and tissues.
This makes the CAB19123 antibody an essential tool for studies in neuroscience, molecular biology, and neurodegenerative disease research.Furthermore, understanding the role of TDP43 in disease pathology is crucial for developing potential therapeutic interventions for neurodegenerative conditions. With its high specificity and sensitivity, the CAB19123 antibody offers researchers a reliable means to investigate the mechanisms underlying TDP43-related diseases and explore new treatment strategies.
Product Name:
TDP-43/TARDB Rabbit Monoclonal Antibody
SKU:
CAB19123
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human TDP-43/TARDB (Q13148).
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Purification Method:
Affinity purification
Gene ID:
23435
Clone Number:
ARC0492
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TDP-43/TARDBP Rabbit mAb (CAB19123) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
