The TDP2 Polyclonal Antibody is a valuable tool for researchers studying TDP2, a DNA repair enzyme involved in processing DNA topoisomerase cleavage complexes. This antibody, raised in rabbits, is highly specific to human TDP2 and is validated for use in Western blot applications. By binding to the TDP2 protein, this antibody enables the detection and analysis of TDP2 levels in various cell types, making it ideal for research in DNA repair and genomic stability.
TDP2 is critical for maintaining genomic integrity by resolving DNA damage induced by topoisomerase inhibitors and other genotoxic agents. Dysregulation of TDP2 has been implicated in diseases such as cancer and neurodegenerative disorders, highlighting the importance of studying its role in DNA repair pathways. Researchers can use this antibody to better understand the function of TDP2 and its potential therapeutic implications in disease treatment.
Product Name:
TDP2 Polyclonal Antibody
SKU:
CAB21536
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human TDP2 (NP_057698.2).
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
Purification Method:
Affinity purification
Gene ID:
51567
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and TDP2 knockout (KO) HeLa(KO) cells, using [KO Validated] TDP2 Rabbit pAb (CAB21536) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
